Adjustable-prescription orthodontic bracket assemblies are disclosed herein. The orthodontic bracket assemblies include a bracket body, an arcuate core, and a retention structure. The bracket body defines an arcuate receptacle that extends toward a base of the bracket body from a top of the bracket body. The arcuate core is received within the arcuate receptacle and defines an archwire slot. The arcuate receptacle is shaped to retain the arcuate core therein and to permit rotation of the arcuate core therein. The retention structure is configured to selectively retain the arcuate core at a selected rotational orientation with the bracket body. The retention structure is configured to selectively transition between a disengaged configuration, in which the retention structure permits rotation of the arcuate core relative to the bracket body, and an engaged configuration, in which the retention structure retains the arcuate core at the selected rotational orientation.
