USTAV MAKROMOLEKULARNI CHEMIE AKADEMIE VEDCESKE REPUBLIKY; V.V.I
发明人:
HORAK, DANIEL,SYKOVA, EVA,BABIC, MICHAL,JENDELOVA, PAVLA,HAJEK, MILAN
申请号：
CA2642779
公开号：
CA2642779C
申请日:
2007.02.23
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention concerns superparamagnetic nanoparticle probes based on ironoxides withmodified surface, method of their preparation and application. The probe ismodified on itssurface by a modification agent selected from the group consisting of mono-,di- andpolysaccharides, poly(amino acid)s and polymers of (meth)acrylic acidderivatives, and form acolloid consisting of particles with narrow size distribution withpolydispersity index lower than1.3, the average size of which ranges from 10 to 30 nm, iron oxide contentamounts to 70-99.9wt.%, the modification agent content makes 0.1-30 wt.%. The probes can be usedfor labellingcells used in magnetic resonance imaging for monitoring their movement,localization, survivaland differentiation especially in detection of pathologies with celldysfunction and of tissueregeneration and also for labelling and monitoring cells administered for celltherapy purposes inthe recipient organism by magnetic resonance.
