Provided is a medicine application tool set capable of reliably discharging an appropriate amount of a medicine, and preventing the problem regarding the reduction of medicinal effect caused by the reduction of a volatile constituent in the case of a volatile medicine. The medicine application tool set is provided with a cylinder (10) having a discharge port for a medicine, a medicine pressing tool (1) provided with a pressing tool (20) which moves along the cylinder, and a medicine containing container (4) in which a gel-form medicine is sealed so as to be openable, wherein the pressing tool (20) is provided with a shaft portion (21) inserted in the cylinder (10) and a pressing-use operation portion (22) connected to the shaft portion, and the cylinder (10) is provided with an insertion port (13) from which the medicine containing container is inserted and an abutting portion (14) which abuts a surface to which the medicine is applied.