INDUSTRY-ACADEMIC COOPERATION FOUNDATION; YONSEI UNIVERSITY
发明人:
YOOK, Jong In,육종인,KIM, Hyun Sil,김현실,KIM, Nam Hee,김남희,NO, Kyoung Tai,노경태,CHOI, Ji Won,최지원,AHN, Sung Yong,안성용
申请号：
KRKR2018/000396
公开号：
WO2018/128517A1
申请日:
2018.01.09
申请国别(地区):
WO
年份:
2018
代理人:
摘要：
The present invention relates to: a composition containing niclosamide or pharmaceutically acceptable salts thereof as an active ingredient, for inhibiting Ras and a pharmaceutical composition containing niclosamide or pharmaceutically acceptable salts thereof as an active ingredient, for treating cancer recurring due to Ras activation. According to the present invention, cancer recurring due to Ras activation can be effectively prevented or treated using niclosamide, which is a safe drug approved by the FDA.La présente invention concerne : une composition contenant comme principe actif du niclosamide ou des sels pharmaceutiquement acceptables de ce dernier, servant à inhiber Ras et une composition pharmaceutique, contenant comme principe actif du niclosamide ou des sels pharmaceutiquement acceptables de ce dernier, utilisée pour traiter une récurrence du cancer liée à une activation de Ras. Selon la présente invention, une récurrence du cancer liée à une activation de Ras peut être efficacement empêchée ou traitée à laide du niclosamide, qui est un médicament sûr approuvé par la FDA.본 발명은 니클로사미드 또는 그의 약학적으로 허용가능한 염을 유효성분으로 함유하는 Ras 억제용 조성물 및 니클로사미드 또는 그의 약학적으로 허용가능한 염을 유효성분으로 함유하는 Ras 활성화에 의해 재발되는 암에 대한 치료용 약학 조성물에 관한 것으로, 본 발명에 따르면, FDA에서 승인받은 안전한 약물인 니클로사마이드를 이용하여, Ras에 의하여 재발되는 암을 효과적으로 예방 또는 치료할 수 있다.
