Steven R. Brant,Amir Karban,Franklin Nouvet,Theodore M. Bayless,James J. Potter,Esteban Mezey,Toshihiko Okazaki
申请号:
US13290678
公开号:
US20120122761A1
申请日:
2011.11.07
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention discloses a functional relationship between a recognized disease condition and a polymorphism in the nucleotide factor kappa B promoter (NFKB1). This relationship provides a platform for methods of altering promoter activity and for determining similar relationships between specific pathologies and identified polymorphisms. A statistically significant risk of developing ulcerative colitis was shown to be correlated with the presence of an ATTG insertion/deletion in the NFKB1 promoter and is likely to apply also to a variety of other inflammatory diseases.