가톨릭대학교 산학협력단;CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION;CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATIONFOUNDATION
发明人:
LEE, EUN HUI,이은희,LEE, KEON JIN,이건진,WOO, JIN SEOK,우진석,LEE, EUN HUIKR,LEE, KEON JINKR,WOO, JIN SEOKKR
申请号：
KR1020120123687
公开号：
KR1020140057051A
申请日:
2012.11.02
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
The present invention relates to a composition for the prevention or treatment of brody disease and brody syndrome comprising a mitsugumin 53 (MG53) inhibitor, and a disease treatment method using the composition for the prevention or treatment of brody disease and brody syndrome comprising a MG53 inhibitor. In addition, the present invention relates to a method for screening a therapeutic agent for muscle diseases by determining a medicine which inhibits interaction between MG53 and sarcoplasmic reticulum Ca2+-ATPase 1a (SERCA1a) as the therapeutic agent for muscle diseases including brody disease and brody syndrome.본 발명은 MG53 (mitsugumin 53) 저해제를 포함하는, 브로디병 또는 브로디신드롬의 예방 또는 치료용 약학 조성물, 및 이를 이용한 질환 치료 방법에 관한 것이다. 또한, 본 발명은 MG53 및 SERCA1a (sarcoplasmic reticulum Ca2+-ATPase 1a)의 상호작용을 억제하는 약제를 브로디병 또는 브로디신드롬을 비롯한 근육 질환 치료제로 결정함으로써, 근육 질환 치료제를 스크리닝하는 방법에 관한 것이다.
