A new and distinct Echeveria×Pachyphytum cultivar named ‘Asante Sana’ which is characterized by large, thick foliage with a slight upwardly curved attitude, arranged in a compact rosette. The obovate to broad oblanceolate foliage is heavily pruinose and exhibits a white coloration with a soft blue hue. The new variety has shown to be uniform and stable in the resulting generations from asexual propagation.