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Spiro-oxindole compounds and their uses as therapeutic agents
专利权人:
XENON PHARMACEUTICALS INC.
发明人:
CHAFEEV, MIKHAIL,CHOWDHURY, SULTAN,FRASER, ROBERT,FU, JIANMIN,KAMBOJ, RAJENDER K.,HOU, DUANJIE,LIU, SHIFENG,BAGHERZADEH, MEHRAN SEID,SVIRIDOV, SERGUEI,SUN, SHAOYI,SUN, JIANYU,CHAKKA, NAGASREE,HSIEH, T
申请号:
ES11009687
公开号:
ES2488618T3
申请日:
2006.04.11
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A process for preparing a compound of formula (I) according to Reaction Scheme 1: ** Formula ** in which: each X is independently chlorine or bromine; R "is alkyl; R1 is hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heterocyclyl, -R8-C (O) R5, -R8-C (O) OR5, -R 8-C (O) N (R4) R5, -S (O) 2-R5, -R9-S (O) m-R5 (where m is 0, 1 or 2), -R 8-OR5, -R 8-CN , -R9-P (O) (OR5) 2, or -R9-O-R9-OR-5; or R1 is aralkyl substituted by -C (O) N (R6) R7 where: R6 is hydrogen, alkyl, aryl or aralkyl; and R7 is hydrogen, alkyl, haloalkyl, -R9-CN, -5 R9-OR5, -R9-N (R4) R5, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, or heteroarylalkyl; or R6 and R7, together with the nitrogen to which they are attached, can form a heterocyclyl or heteroaryl; and in which each aryl, aralkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl and heteroarylalkyl group for R6 and R7 may optionally be substituted by one or more substituents selected from the group consisting of alkyl, cycloalkyl, aryl, aralkyl, halo, ha loalkyl, -R8-CN, -R8-OR5, heterocyclyl and heteroaryl; or R1 is aralkyl optionally substituted by one or more substituents selected from the group consisting of -R8-OR5, -C (O) OR5, halo, haloalkyl, alkyl, nitro, cyano, aryl, aralkyl, heterocyclyl and heteroaryl; or R1 is -R9-N (R10) R11, -R9-N (R12) C (O) R11 or -R9-N (R10) C (O) N (R10) R11 where: each R10 is hydrogen, alkyl, aryl, aralkyl or heteroaryl.Un procedimiento para preparar un compuesto de fórmula (I) de acuerdo al Esquema de reacción 1:**Fórmula** en el que: cada X es independientemente cloro o bromo; R" es alquilo; R1 es hidrógeno, alquilo, alquenilo, alquinilo, haloalquilo, arilo, cicloalquilo, cicloalquilalquilo, heteroarilo, heterocicliclo, -R8-C(O)R5, -R8-C(O)OR5, -R 8-C(O)N(R4)R5, -S(O)2-R5, -R9-S(O)m-R5 (donde m es 0, 1 o 2), -R 8-OR5, -R 8-CN, -R9-P(O)(OR5)2, o -R9-O-R9-OR-5; o R1 es aralquilo sustituido por -
来源网站:
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