INSERT THERAPEUTICS, INC.;CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人:
HWANG PUN, SUZIE,GONZALEZ, HECTOR,DAVIS, MARK E.,BELLOCQ, NATHALIE,CHENG, JIANJUN
申请号：
CA2431207
公开号：
CA2431207C
申请日:
2001.12.19
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
The invention provides a composition containing particulate composite of apolymer and a therapeutic agent. The composition also contains a complexingagent. The polymer interacts with the complexing agent in a host-guest or aguest-host interaction to form an inclusion complex. A therapeutic compositionof the invention may be used to deliver the therapeutic agent and to treatvarious disorders. Both the polymer of the particulate composite and thecomplexing agent may be used to introduce functionality into the therapeuticcomposition. The invention also relates to a method of preparing acomposition. The method combines a therapeutic agent, a polymer having host orguest functionality, and a complexing agent having guest or host functionalityto form the therapeutic composition. The complexing agent forms an inclusioncomplex with the polymer. The invention also relates to a method of deliveringa therapeutic agent. According to the method, a therapeutically effectiveamount of a therapeutic composition of the invention is administered to amammal (e.g. person or animal) in recognized need of the therapeutic.
