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Virus inactivation OF caprylate
专利权人:
ГРИФОЛЬС; С.А. (ES)
发明人:
ЛЕБИНГ Витольд (US),БЕРНС Даг (US),РОТ Нейтан (US),ХОТТА Джоан (US)
申请号:
RU2013134696/15
公开号:
RU2013134696A
申请日:
2013.07.24
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A process for preparing albumin from a solution containing albumin, comprising: adjusting the protein concentration of the solution to a value of less than about 5%, adjusting pH value of the solution to a pH value, of approximately 5 or less adding caprylic acid (octanoic acid) or sodium caprylate solution temperature rise above about 20 ° C and incubation rastvora.2. A method according to Claim. 1, where the incubation temperature is 27-30 ° C.3. . A method according to claim 1, wherein incubation is performed for about 30 min - about 120 Min.4. A method according to Claim. 1, where the incubation is performed at least for about 90 min.5. A method according to claim 1, wherein the concentration of caprylate is approximately 10 mM -. Approximately 40 mM.6. A method according to claim 1, wherein caprylate concentration is approximately 15 mM -. Approximately 30 mM.7. A method according to Claim. 1, where caprylate concentration is about 20 mM.8. The method of claim 1 wherein the pH value is about 3.8 -. About 5.9. A method according to Claim. 1, where the pH value is about 5.10. A method according to claim 1, which further comprises: filtering the solution perform ultrafiltration and diafiltration preparation and increase the volume of solution. isterilizatsiyu, filling tanks, and pasteurization albumina.11. A process for preparing albumin from a solution containing albumin, comprising: adjusting the protein concentration of the solution to a value of less than about 5%, bringing the value of approximately 5 pH of the solution to pH, or less adding caprylic acid (octanoic acid) or caprylate up to sodium1. Способ получения альбумина из раствора, содержащего альбумин, который содержит:доведение концентрации белка раствора до значения, составляющего меньше чем приблизительно 5%доведение значения pH раствора до значения pH, составляющего приблизительно 5, или меньшедобавление каприловой кислоты (октановой кислоты) или каприлата натрия повышение температуры раствора в
来源网站:
中国工程科技知识中心
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