Present invention relates to Cefpodoxime self microemulsifying dosage compositions of low solubility. In particular, present invention to optimization of components of Cefpodoxime self microemulsifying composition. The self emulsifyingcefpodoxime composition of present invention comprisescefpodoxime, an oil, a surfactant and a co-surfactant, wherein amount of cefpodoxime in composition ranges from 10 to 20 % w/w % w/w of total compositionamount of oil in composition ranges from 10 to 30 % w/w of total compositionamount of surfactant in composition ranges from 30 to 50 % w/w of total composition and amount of co-surfactant in composition ranges from 30 to 60 % w/w of total composition.
