The invention relates to antibacterial compounds of formula I wherein R is H, cyano, alkoxy, cyanomethoxy, cycloalkylmethoxy, hydroxyalkoxy, alkoxyalkoxy, alkoxycarbonyl, 2-ethoxy-2-oxoethoxy, 2-(methylamino)-2-oxoethoxy, (1-cyanocyclobutyl)methoxy, 3-hydroxy-pyrrolidin-1-yl or 3,4-dihydroxycyclopentyl)methoxy U1 is N or CR1, U2 is N or CR2, U3 is N or CR3 and U4 is N or CR4, it being understood that at most three of U1, U2, U3 and U4 can be N at the same time V1 is N or CR5, V2 is N or CR6, V3 is N or CR7 and V4 is N or CH, it being understood that at most two of V1, V2, V3 and V4 can be N at the same time R1 is H, cyano, hydroxy or alkoxy R2 is H, hydroxy or alkoxy R3 is H, cyano, hydroxy, alkoxy or carboxamido R4 is H or alkoxy R5 is H, hydroxy or halogen R6 is H, hydroxy or halogen R7 is H the dotted line “-----” represents a bond or is absent W represents CH or N when the dotted line “-----” is a bond, or W represents CH2 when the dotted line “-----” is absent X represents CH or N and Q represents O or S and salts thereof.本發明係關於一種式I抗菌化合物及其鹽,其中R係H、氰基、烷氧基、氰基甲氧基、環烷基甲氧基、羥基烷氧基、烷氧基烷氧基、烷氧基羰基、2-乙氧基-2-側氧基乙氧基、2-(甲基胺基)-2-側氧基乙氧基、(1-氰基環丁基)甲氧基、3-羥基-吡咯啶-1-基或(3,4-二羥基環戊基)甲氧基;U1係N或CR1,U2係N或CR2,U3係N或CR3及U4係N或CR4,應明白U1、U2、U3及U4中之至多三者可同時為N;V1係N或CR5,V2係N或CR6,V3係N或CR7及V4係N或CH,應明白V1、V2、V3及V4中之至多兩者可同時為N;R1係H、氰基、羥基或烷氧基;R2係H、羥基或烷氧基;R3係H、氰基、羥基、烷氧基或甲醯胺基;R4係H或烷氧基;R5係H、羥基或鹵素;R6係H、羥基或鹵素;R7係H;虛線「-----」表示鍵結或不存在;當虛線「-----」係鍵結時,W表示CH或N,或當虛線「-----」不存在時,W表示CH2;X表示CH或N;及Q表示O或S。
