ZIMMER, Robert H.,GUICHARD, Gilles,FREMAUX, Juliette,VENIN, Claire,GOUDREAU, Sebastien
申请号:
AU2018293467
公开号:
AU2018293467A1
申请日:
2018.06.29
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
The present disclosure relates to a pro-drug peptide, or a salt thereof, having improvement for at least one biological property relative to a parent peptide or peptidomimetic, wherein the biological property is selected from the group consisting of therapeutic index, stability, solubility, toxicity, adsorption, and pre-systemic metabolism. The pro-drug peptide comprising the following structure: Z-pep, wherein: pep is the parent peptide or peptidomimetic; Z is a sequence of n amino acids, Z is cleaved