A method to slow down and mitigate aging and to maintain health by administering a composition comprising at least one protein-homeostasis-influencing saccharide-based substance, an anti-amyloidogenic substance, a Krebs cycle metabolite, glycine, gingko biloba, low dose lithium, a prebiotic, or combinations thereof, enabling a synergistic and enhancing effect on the aging process and well-being due to their interaction and synergetic influence on protein homeostasis and various other aging-related mechanisms.