In an embodiment, there is a safety scalpel having a handle, and a replaceable blade cartridge assembly that is releasably attached to the handle. The handle comprises a first end and a second end. The blade cartridge assembly comprises a housing that can be slideably mounted onto the second end of the handle, a blade holder that can be disposed within the housing, and a blade that can be attached to the blade holder. The safety scalpel has a resilient lock member that prevents the cartridge assembly from being detached from the handle during use.在一具體例中，提出一種安全手術刀，具有：握柄及可卸除地附接至握柄的可更換刀片匣總成。握柄包括第一端及第二端。刀片匣總成包括：可滑動地安裝至握柄之第二端上的外殼、可設置在外殼內的刀片夾持器及可附接至刀片夾持器的刀片。此安全手術刀具有在使用期間防止刀片匣總成脫離其握柄的彈性鎖定構件。
