The present invention provides antibodies that bind to the cat allergen, Fel d1, compositions comprising the antibodies, nucleic acids encoding the antibodies and methods of use of the antibodies. According to certain embodiments of the invention, the antibodies are fully human monoclonal antibodies that bind to Fel d1. The antibodies of the invention are useful for binding to the Fel d1 allergen in vivo, thus preventing binding of the Fel d1 allergen to pre-formed IgE on the surface of mast cells or basophils. In doing so, the antibodies act to prevent the release of histamine and other inflammatory mediators from mast cells and/or basophils, thus ameliorating the untoward response to the cat allergen in sensitized individuals. The antibodies of the invention may also be useful for diagnostic purposes to determine if a patient is allergic to the Fel d1 cat allergen.本發明係提供與貓過敏原Fel d1結合之抗體、包括此等抗體之組成物、編碼此等抗體之核酸以及使用此等抗體之方法。根據本發明特定的實施例，此等抗體為與Fel d1結合之全人類單株抗體。本發明之抗體可用於活體內與Fel d1過敏原結合，因而防止Fel d1過敏原與肥大細胞或嗜鹼性細胞表面上之預形IgE結合。如此一來，此等抗體係用作防止組織胺和其他發炎介質從肥大細胞及/或嗜鹼性細胞釋放出，因而改善致敏個體中對貓過敏原之不良反應。本發明之抗體亦可用於診斷目的，測定病患是否對Fel d1貓過敏原過敏。
