Tian Xu,Cong Xu,Danyang Liu,Jieqing Fan,Yanfang Pan,Tongruei Raymond Li,Xiaodong Chen
申请号：
US16395463
公开号：
US20190367553A1
申请日:
2019.04.26
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A1, A2, L1, L2, L3, Z1, Z2, W1, W2, R1, R2, R3, R4, R5, R6 and R7 are defined herein.
