Vahe Bedian;Karin Kristina Amundson;Dana Dan Hu-Lowe;Shelley Sims Belouski;James Arthur Thomson;Shannon Marie Karlicek;Xin Jiang;Sirid-Aimée Kellerman;Jianying Wang;Grant Raymond W;Michael Aidan North
发明人:
Shelley Sims Belouski,Sirid-Aimée Kellerman,Michael Aidan North,Karin Kristina Amundson,Vahe Bedian,Dana Dan Hu-Lowe,Xin Jiang,Shannon Marie Karlicek,James Arthur Thomson,Jianying Wang,Grant Raymond W
申请号：
US13282065
公开号：
US20120052074A1
申请日:
2011.10.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like, kinase-1 (ALK-1) and that function to abrogate the ALK-1/TGF-beta-1/Smad1 signaling pathway. The invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
