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Hexahydrodibenzo[a,g]quinolizine compound, preparation method thereof, pharmaceutical composition and use thereof
专利权人:
SHANGHAI INSTITUTE OF MATERIA MEDICA; CHINESE ACADEMY OF SCIENCES
发明人:
Hong Liu,Xin Xie,Xuechu Zhen,Haifeng Sun,Jing Li,Liyuan Zhu,Zeng Li,Ying Chen,Hualiang Jiang,Kaixian Chen
申请号:
US14683726
公开号:
US09359372B2
申请日:
2015.04.10
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention relates to a novel hexahydrodibenzo[a,g]quinoline compound represented by general formula (I) and its derivatives, enantiomer, diastereoisomer, raceme and mixtures thereof, as well as pharmaceutically acceptable salts thereof. The present invention further relates to a method for preparing the compound, and the compound has good prevention and treatment effect on neurological diseases, especially diseases associated with dopamine receptor and 5-hydroxytryptamine receptor. The bioactivity experiment demonstrates that, the compound is expected to be developed into a novel and potent chemical entity for treating diseases associated with dopamine receptor and 5-hydroxytryptamine receptor, especially schizophrenia, Parkinson's disease, drug addiction, migraine and so on.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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