The invention relates to a method of conferring to a plant resistance against a plant disease caused by a Fusarium species, to a transgenic Fusarium-resistant plant, to a double-stranded RNA and a composition comprising same. Object of the invention is the provision of means for reducing susceptibility of food crops, in particular cereals, to fungal attack. For this purpose, the present invention provides in one aspect a method of conferring to a plant resistance against a plant disease caused by a Fusarium species, the method comprising genetically engineering the plant in a manner to enable host-induced gene silencing of a Fusarium gene encoding CSX1 having or comprising the amino acid sequence of SEQ ID NO: 2 or of a Fusarium gene encoding a protein sharing at least 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% sequence identity with the amino acid sequence of SEQ ID NO: 2.
