ST. GEORGES HOSPITAL MEDICAL SCHOOL;ST. GEORGE'S HOSPITAL MEDICAL SCHOOL, CRANMER TERRACE;THE UNIVERSITY OF MANCHESTER; CRANMER TERRACE
发明人:
ROBINSON CLIVE,ZHANG JIHUI,GARROD DAVID RONALD,PERRIOR TREVOR ROBERT,NEWTON GARY KARL,JENKINS KERRY,BEEVERS REBEKAH ELISABETH,MAYOR MERIEL RUTH,STEWART MARK RICHARD,ROBINSON Clive,ZHANG Jihui,GARROD David Ronald,PERRIOR Trevor Robert,NEWTON Gary Karl,JENKINS Kerry
申请号：
SI201130565
公开号：
SI2526116T1
申请日:
2011.01.21
申请国别(地区):
SI
年份:
2015
代理人:
摘要：
The present invention pertains generally to the field of therapeutic compounds and more specifically to certain pyruvamide compounds of the formula (X) (for convenience, collectively referred to herein as "PVA compounds"), which, inter alia, inhibit a dust mite Group 1 peptidase allergen (e.g., Der p 1, Der f 1, Eur m 1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit a dust mite Group 1 peptidase allergen, and in the treatment of diseases and disorders that are mediated by a dust mite Group 1 peptidase allergen； that are ameliorated by the inhibition of a dust mite Group 1 peptidase allergen； asthma； rhinitis； allergic conjunctivitis； atopic dermatitis； an allergic condition which is triggered by dust mites； an allergic condition which is triggered by a dust mite Group 1 peptidase allergen； and canine atopy.
