COMPOSITION DESTINÉE À LA PROLIFÉRATION, À LA PROMOTION DE LA DIFFÉRENCIATION, OU À L'INHIBITION DE LA SÉNESCENCE DE CELLULES SOUCHES, CONTENANT L'INHIBITEUR JAK1 COMME INGRÉDIENT ACTIF
University Of Ulsan Foundation For Industry Cooperation
发明人:
KIM, Seong-Who,KIM, Sang-Yoon,LEE, Hyang-Ju
申请号：
EP17763586
公开号：
EP3461887A4
申请日:
2017.03.09
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention relates to a composition for proliferation, differentiation promotion, and senescence inhibition of stem cells, comprising a JAK1 inhibitor as an active ingredient. JAK1 inhibitor-treated stem cells or JAK1 knockout stem cells, of the present invention, have an activity for decreasing senescence and increasing the survival rate of the stem cells, thereby being usable in a composition for proliferation, differentiation promotion, and senescence inhibition of stem cells. In addition, JAK1 knockout stem cells have an activity for inhibiting or decreasing the expression of HLA-A or HLA-B, which is an immunogenicity related protein, and promoting or increasing the expression of TGF-b or HGF, which is a T cell activity inhibitory protein, thereby also being usable in the prevention or treatment of immune diseases.
