MAKALLISTER Devin (US),МАКАЛЛИСТЕР Дэвин (US),PRAUSNITS Mark (US),ПРАУСНИЦ Марк (US),GENRI Sebastien (US),ГЕНРИ Себастиен (US),GO Sin Dun (US),ГО Синь Дун (US)
申请号：
RU2016145275
公开号：
RU0002719937C1
申请日:
2015.04.24
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
FIELD: medicine； medical equipment.SUBSTANCE: group of inventions relates to the field of application of microneedles for transportation of therapeutic, diagnostic, cosmetic, biological or other molecules inside the skin, beyond or through it or other fabric barriers. Matrix of microneedles for introduction of required substance into biological tissue contains main substrate having microneedle and opposite back side, a primary funnel-shaped portion extending from the micro-needle side of the base substrate, and two or more solid microneedles extending from the primary funnel-shaped portion. Two or more solid microneedles contain the required substance. Microneedle patch comprises a previously described microneedle matrix, an adhesive layer and an auxiliary layer attached to the base substrate. Auxiliary layer comprises tongue portion extending from one or more hard microneedle to allow user to retain tongue portion to manipulate patch without contact with two or more solid microneedles. Method of forming a microneedle array includes: (a) providing a casting mold having a top surface, an opposite bottom surface and a top surface opening, wherein the hole communicates with the first cavity proximal to the upper surface and with the second cavity located below the first cavity, wherein the first cavity defines the primary part of the funnel, wherein the second cavity defines at least one microneedle； (b) filling at least a second cavity through a hole in a casting mold with a first material which contains the desired substance dissolved or suspended in a first liquid medium； (c) drying the first material in the casting mold to remove at least a portion of the first liquid medium to form at least a portion of the sharpened end of the microneedle in the second cavity, wherein a portion of the pointed end comprises the desired substance； (d) filling the first cavity and the second cavity, provided that any of them is unoccupied during steps (b) and (c), through a hole in
