PFEIFER, ANDREA,SCHRATTENHOLZ, ANDRE,MUHS, ANDREAS
申请号：
NZ58231408
公开号：
NZ582314A
申请日:
2008.07.02
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is the use of pirenzepine derivative represented by general formula (I), such as clozapine, for the treatment of a disease or condition, which is caused by or associated with the formation of beta-amyloid plaques in the brain, in an animal suffering from said disease or condition by (a) reducing the beta-amyloid plaque load, and/or (b) inhibiting the formation of beta-amyloid plaques and/or (c) retarding the increase of amyloid load in the brain of the treated animal, thereby retaining or increasing cognitive memory capacity in said animal. Such diseases can include Guam Parkinson-Dementia complex diseases based on or associated with amyloid-like proteins Creutzfeld Jacob disease, Parkinsons disease, HIV-related dementia, ALS (amyotropic lateral sclerosis), Adult Onset Diabetes senile cardiac amyloidosis endocrine tumors, macular degeneration, drusen-related optic neuropathy and cataract due to beta-amyloid deposition.
