Mdc Max-Delbrück-Centrum Für Molekulare Medizin Berlin - Buch;Fresenius Medical Care Deutschland GmbH
发明人:
KUNZE, Rudolf,WALLUKAT, Gerd,ROSENTHAL, Peter,STRAUBE, Richard
申请号：
ES09702027
公开号：
ES2639573T3
申请日:
2009.01.15
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
Peptide having an ED50 of less than 500 nM, in particular 10 nM against an antibody that recognizes an epitope in a loop 2 of a1 or loop 1 of extracellular b2 of a human adrenergic receptor (AR) in which the binding of the antibody to the epitope results in increased g-secretase activity, an increased release of b-amyloid molecules, in which the DE50 value is measured by a bioassay； and in which the peptide consists of an amino acid sequence X1-X2-X3-X4-X5-X6-X7-X8-X9 in which a) X1>； = amino group, amide, acetyl group, biotin group, marker, spacer, linker, C, GKK, SGKK or deletion, X2>； = A, G, a-Abu, F, Hph, Hyp, Nal, P, Pip, S, V, W, Y or deletion, X3>； = Hyp, P, Pip, S, T, Y or deletion, X4>； = Aad, Asu, D, E, Har, K, N, Orn, Q, R, X5>； = Aad, Asu, D, E, N, Q, X6>； = Aad, Asu, D, E, Har, K, N, Orn, Q, R, X7>； = F, Hph, Hyp, Nal, P, Pip, W, Y or deletion, X8>； = A, a -Abu, bA, G, S, T, V, Y or deletion, X9>； = amide, hydrazide, azide, carbamate, marker, spacer, linker, C, GKK, SGKK or deletion, or b) X1>； = amino group, amide, acetyl group, biotin group, marker, spacer, linker, C, GKK, SGKK or deletion, X2>； = F, Hph, Hyp, Nal, P, Pip, W, Y, X3>； = A, a-Abu, Dab, G, Hyl, K, Orn, R, S, V, X4>； = Aad, Asu, D, E, Hyp, N, P, Pip, Q, X5>； = Aad, Asu, D, E, Hyp, N, P, Pip, Q, X6>； = A, a-Abu, G, Hyl, K, Orn, R, S, V X7>； = F, Hph, Hyp, Nal, P, Pip, W, Y, X8>； = g-Abu, Ahx, bA, G or deletion, X9>； = amide, hydrazide, azide, carbamate, marker, spacer, linker, C, GKK, SGKK or deletion, oc) X1>； = amino group, amide, acetyl group, biotin group, marker, spacer, linker, C, GKK, SGKK or deletion, X2>； = A, a-Abu, Dab, G, Hyl, K, Orn, R or deletion, X3>； = A, C, F, Hph, M, Nal, S, W, Y, X4>； = F, S, T, W, Y, X5>； = F, S, T, W, Y, X6>； = A, C, F , Hph, M, Nal, S, W, Y, X7>； = A, a-Abu, Dab, G, Hyl, K, Orn, R, X8>； = Abu, Ahx, bA, G or deletion, X9>； = amide, hydrazide, azide, carbamate, marker, spacer, linker, C, 5 GKK, SGKK
