PROBLEM TO BE SOLVED: To provide a novel controlled release carrier material capable of successively releasing a transportation carrier of drug delivery and functional molecule such as useful peptide or fluorescent molecule.SOLUTION: There is provided a controlled release carrier material in which: in neutral solution, N-to-O acyl group transposition reaction with amide bond cleavage (formation of diketopiperazine) occurs using a compound having a serine-prolyl ester bond and similar structure thereof, and then a functional molecule is released by hydrolysis at the generated ester part and molecule is designed so that such reaction occurs successively (in cascade) to successively release different kinds of functional molecules.COPYRIGHT: (C)2015,JPO&INPIT【課題】ドラッグデリバリーの輸送担体と有用なペプチドや蛍光分子等の機能性分子を逐次放出可能な新規な徐放担体材料の提供。【解決手段】セリン-プロリルエステル結合及びその類似構造を有する化合物を用いることで、中性水溶液中において、アミド結合切断を伴うN-to-Oアシル基転移反応が進行し(ジケトピペラジンが形成され)、続いて生成したエステル部分にて加水分解を受けることで機能性分子が放出されること、及び、かかる反応を連続的(カスケード)に起こるように分子設計することで異なる種類の機能性分子を逐次放出できる徐放担体材料。【選択図】なし
