The Government of the United States of America; as represented by the Secretary of the Navy
发明人:
James B. Delehanty,Michael H. Stewart,Okhil Nag,Jeffrey R. Deschamps,Kimihiro Susumu,Eunkeu Oh,Lauren D. Field,Alexander L. Efros,Alan L. Huston,Igor L. Medintz,Philip E. Dawson,Nashaat Rasheed,Parag
申请号：
US16031094
公开号：
US20180326097A1
申请日:
2018.07.10
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A construct for detecting cellular membrane potential includes a nanoparticle operable as an electron donor； a modular peptide attached to the nanoparticle, the peptide comprising a nanoparticle association domain, a motif configured to mediate peptide insertion into the plasma membrane, and at least one attachment point for an electron acceptor positioned at a controlled distance from the nanoparticle； and an electron acceptor. The nanoparticle can be a quantum dot and the electron acceptor can be C60 fullerene. Photoacoustic emission from the construct correlates with cellular membrane potential.
