The present invention provides the compound or its salt of the expression of Yi Zhong oxazole compounds (1) formulas: whereR1 is aryl, can have one or more substituent groups in this way； R2 be aryl or nitrogen-atoms heterocyclic group each can have one or more substituent groups； The bivalent group indicated with W, or pass through-Y1-A1--Y2-C (group)-wherein Y1 groups such as-c (group), A1 groups such as lower alkylene groups, and Y2 groups such as piperazinediyl groups. Azole compounds have specific inhibitory effect to phosphodiesterase 4.
