Hans-Guido Wendel,Andrew L. Wolfe,Konstantinos John Mavrakis,Elisa Oricchio,Adolfo A. Ferrando,Kim De Keersmaecker,Teresa Palomero,Franki Speleman,Pieter Van Vlierberghe
申请号：
US13581032
公开号：
US20130064810A1
申请日:
2011.02.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to microRNAs (miRNAs) which are associated with cancer, particularly including hematologic malignancies, and particularly T-cell acute lymphoblastic leukemia (T-ALL), and to the assessment and modulation thereof in the treatment and management of cancer. The present invention is directed to methods and compositions for diagnosing and treating cancer, particularly T-ALL, by modulating miRNAs, and the use of miRNAs and antagonists thereof, particularly antagomirs, for predicting and assessing response to treatment, in assays for isolating and selecting antagists, and as compositions for the treatment and management of cancer. Methods and compositions are provided for treatment or alleviation of cancer, particularly T-ALL, with antagonists/antagomirs of miRNAs, particularly one or more of miR-19b, miR-20a, miR26, miR92, miR148 and miR223.
