The present invention relates to stenosis therapy planning. A first volumetric data set is received by medical imaging of at least part of an artery comprising a stenosis. At least one two-dimensional image data (of the stenosis is received. A first arterial pressure drop is determined around the stenosis. A second volumetric data set is generated by registering the at least one two-dimensional image data with the first volumetric data set. A third volumetric data set is generated by simulating a geometry modification of the stenosis in the second volumetric data set and a second arterial pressure drop is estimated around the stenosis in the third volumetric data set.
