A medical device includes a structure configured for introduction to a vascular system of a patient. A method of fabricating the medical device is provided, the method comprising: mixing a base material with nitroprusside and an antimicrobial agent, wherein the antimicrobial agent comprises chlorhexidine base and/or a pharmaceutically acceptable salt thereof； and melt processing and extruding the mixture to fabricate the tubing for the medical catheter. The sodium nitroprusside has a concentration sufficient to reduce thrombosis.
