DACK, KEVIN NEIL,MILLS, JAMES EDWARD JOHN,SKERRATT, SARAH ELIZABETH
申请号：
NZ59231109
公开号：
NZ592311A
申请日:
2009.10.30
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is an aryl ester substituted pyrrolidine of formula (I). Examples of compounds of formula (I) are: 3-{ [(4'-cyanobiphenyl-4-yl)oxy]methyl} -1-( 4-fluorobenzoyl )pyrrolidine-3-carboxylic acid； 3-{ [(4'-cyanobiphenyl-4-yl)oxy]methyl} -1-(4-methoxybenzoyl)pyrrolidine-3-carboxylic acid and 3-{ [4-(5-chloropyrimidin-2-yl)phenoxy]methyl} -1-(4-fluorobenzoyl)pyrrolidine-3-carboxylic acid. Also disclosed is a pharmaceutical composition comprising a compound of formula (I) and the use of a compound of formula (I) for the manufacture of a medicament for the treatment of a disease or disorder which would benefit from, or is mediated by, EP2 receptor antagonism such as endometriosis, uterine fibroids (leiomyoma), menorrhagia, adenomyosis, primary and secondary dysmenorrhoea (including symptoms of dyspareunia, dyschexia and chronic pelvic pain), chronic pelvic pain syndrome, polycystic kidney disease or polycystic ovarian syndrome.
