KARIN UTE JOOSS;MICHAEL ROBERT DERMYER;VAN TO TSAI;PFIZER INC.;BRIAN GREGORY PIERCE;JOYCE TSI TAN;HELEN KIM CHO;JOSEPH JOHN BINDER
发明人:
JOSEPH JOHN BINDER,HELEN KIM CHO,MICHAEL ROBERT DERMYER,KARIN UTE JOOSS,BRIAN GREGORY PIERCE,JOYCE TSI TAN,VAN TO TSAI
申请号:
IL25593817
公开号:
IL255938D0
申请日:
2017.11.27
申请国别(地区):
IL
年份:
2018
代理人:
摘要:
The present disclosure provides (a) isolated immunogenic PAA polypeptides; (b) isolated nucleic acid molecules encoding immunogenic PAA polypeptides; (c) vaccine compositions comprising an immunogenic PAA polypeptide or an isolated nucleic acid molecule encoding an immunogenic PAA polypeptide; (d) methods relating to uses of the polypeptides, nucleic acid molecules, and compositions; and (e) vaccine-based immunotherapy regimens which involve co-administration of a vaccine in combination with an immune-suppressive-cell inhibitor and an immune-effector-cell enhancer.