Készítmények és eljárások célzott, emlõssejtekbe történõ, in vitro és in vivo gyógyszerbejuttatásra baktériumból származó minisejtekkel

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专利权人:

EnGeneIC Molecular Delivery Pty Ltd.

发明人:

BRAHMBHATT, Himanshu,MACDIARMID, Jennifer

申请号：

HUE05702361

公开号：

HUE025292T2

申请日:

2005.01.27

申请国别(地区):

HU

年份:

2016

代理人:

摘要：

A composition comprising intact minicells that contain a drug molecule is useful for targeted drug delivery. One targeted drug delivery method employs bispecific ligands, comprising a first arm that carries specificity for a bacterially derived minicell surface structure and a second arm that carries specificity for a mammalian cell surface receptor, to target drug-loaded minicells to specific mammalian cells and to cause endocytosis of the minicells by the mammalian cells. Another drug delivery method exploits the natural ability of phagocytic mammalian cells to engulf minicells without the use of bispecific ligands.

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