The invention discloses controlled release forms, it includes the pharmaceutically active agents of therapeutically effective amount, by acyclovir, its by discharged in about 12 hours no more than about 90% activating agent simulation gastric juice the first order rate release type 1 USP dissolution tests, and without containing solubilizer or expansion reinforcing agent or both, include (a) a piece of, by the polymer substrate of at least two biocompatible polymer, by carbopol 974P and polyethylene oxide, the pharmaceutically active agents and the excipient pharmaceutically allowed mixing The tablet can Fast-swelling will lead to its gastric retention to one without the gastric juice of simulation described in fragmentation under ones belt and started the controlled release of active agents and corroded by the start control and diffusion contact, in above-mentioned gastric juice, or the non-grafted chitosan or chitosan derivatives of (two) microballoon is as illustrated by Thiolation chitosan and trimethyl chitin, or carbopol is mixed with the activating agent, the activating agent is not in stomach after polymer molecule and medication, and the microballoon adhare discharges the active agent to the long-time of gastric mucosa can be in a controlled manner.
