The current application relates to the use of lipase inhibitors for treating acute, sub-acute, or chronic constipation resulting from opiod administration, dehydration, lazy bowel, paralytic bowel, menstruation, bowel resection, and bedridden. Preferred lipase inhibor is selected from orlistat, cetilistat, saponins, cioscin, escins, cyclocanosides, polyphenols, terpenes, and pancreatic lipase inhibitors. The lipase inhibitor can be administered topically, ΓΜ, IV, SC, or mucosally.
