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TARGETED THERAPEUTICS
专利权人:
发明人:
Dinesh U. Chimmanamada,Weiwen Ying
申请号:
US15266411
公开号:
US20170056511A1
申请日:
2016.09.15
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.
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中国工程科技知识中心
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