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Apoptosis signal-regulating kinase inhibitors
专利权人:
Gilead Sciences; Inc.
发明人:
Gregory Notte
申请号:
US14135812
公开号:
US09051313B2
申请日:
2013.12.20
申请国别(地区):
US
年份:
2015
代理人:
摘要:
The present invention relates to compounds of Formula (I):Wherein variables are as defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, COPD, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver diseases, and neurodegenerative diseases.
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