George Y. Daniloff,Robert C. Spiro,David M. Gravett,Patrick J. Hillas,Pingren He
申请号：
US12165607
公开号：
US09011894B2
申请日:
2008.06.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present application provides sterile hyaluronic polymer compositions than are useful, e.g., as medical devices, biomedical adhesives, and sealants. Generally, provided are sterile dry compositions comprising a thiol-derivatized hyaluronic acid and one or more stabilizing excipients. Also provided are related kits and methods. The compositions described herein are particularly robust to sterilizing irradiation, and substantially maintain both their molecular weight and gelation parameters such as gelation time after sterilization, such that such sterile compositions are capable of hydrogel formation.
