MANTZILAS, DIMITRIOS,KARLSON, JAN ROGER,OSTBY, JUDIT TJELMELAND,FRENVIK, JANNE OLSEN
申请号：
CA3010191
公开号：
CA3010191A1
申请日:
2016.12.29
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention provides a method for the purification of 227Th from a mixture comprising 227Th and 223Ra, said method comprising: i) preparing a first solution comprising a mixture of 227Th and 223Ra ions dissolved in an aqueous solution of first mineral acid ii) loading said first solution onto a strong base anion exchange resin iii) eluting 223Ra from said strong base anion exchange resin using a second mineral acid in an aqueous solution iv) optionally rinsing said strong base anion exchange resin using a first aqueous medium v) eluting 227Th from said strong base anion exchange resin using a third mineral acid in an aqueous solution whereby to generate a second solution comprising 227Th. The invention further provides a purified 227Th solution, a corresponding pharmaceutical formulation and methods of treatment of neoplastic disease.
