PENNING, THOMAS,THOMAS, SHEELA,ZHU, GUI-DONG,GANDHI, VIRAJKUMAR,GONG, JIANCHUN,GIRANDA, VINCENT
申请号：
ES06836157
公开号：
ES2378692T3
申请日:
2006.09.28
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound having the formula (I) ** Formula ** or one of its therapeutically acceptable salts, wherein R1, R2, and R3 are independently selected from the group consisting of hydrogen, alkenyl, alkoxy, alkoxycarbonyl, alkyl, alkynyl, cyano , haloalkoxy, haloalkyl, halogen, hydroxy, hydroxyalkyl, nitro, NRARB, and (NRARB) carbonyl； each R4 is independently selected from the group consisting of hydrogen, halogen, alkyl, and haloalkyl； m is 4； Z is a link； A is selected from the group consisting of ** formula ** each R5 is independently selected from the group consisting of alkenyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, cyano, haloalkoxy, haloalkyl , halogen, heterocycle, heterocycloalkyl, heteroaryl, heteroarylalkyl, hydroxy, hydroxyalkyl, NRCRD, (NRCRD) alkyl, (NRCRD) carbonyl, (NRCRD) carbonylalkyl, and (NRCRD) sulfonyl； R6 is selected from the group consisting of hydrogen, alkenyl, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkynyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, heterocycle, heterocycloalkyl, heteroaryl, heteroarylalkyl, hydroxyalkyl, (NRCRD) alkyl, (NRCRD) carbon, (NRCRD) carbon (NRCRD) carbonylalkyl, and (NRCRD) sulfonyl； RA, and RB are independently selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, and cycloalkyl； RC and RD are independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl； and n is 0, 1, 2, or 3.Un compuesto que tiene la fórmula (I) **Fórmula** o una de sus sales terapéuticamente aceptables, donde R1, R2, y R3 se seleccionan independientemente del grupo que consiste en hidrógeno, alquenilo, alcoxi, alcoxicarbonilo, alquilo, alquinilo, ciano, haloalcoxi, haloalquilo, halógeno, hidroxi, hidroxialquilo, nitro, NRARB, y (NRARB)carbonilo； cada R4 se selecciona independientemente del grupo que consiste en hidrógeno, halógeno, alquilo, y haloalquilo； m es 4； Z es un enlace； A se selecciona del grupo q
