MARIA DEL CARMEN ABRAHANTES PEREZ,GLAY CHINEA SANTIAGO,CRUZ MATILDE LOPEZ ABAD,SONIA GONZALEZ BLANCO,EDUARDO MARTINEZ DIAZ,HILDA ELISA GARAY PEREZ,OSVALDO REYES ACOSTA,ERNESTO LOPEZ MOLA
申请号：
ARP120100930
公开号：
AR088727A1
申请日:
2012.03.21
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
These cyclic peptides are used for the preparation of human and / or veterinary therapeutic drugs, and also for diagnosis. These compounds can be used to detect, monitor and / or control various diseases related to cell proliferation, such as tumor diseases and accidental angioplasty. In addition, they can become part of the field of controlled emission systems and nanotechnology,This is because it has the ability to self regulate or be part of other systems. 1. Claim 1: cyclic peptide with anti-tumor and anti angioplasty activity, characterized by its amino acid sequence including: (a) its amino acid sequence is x1-asn-thr-x2-arg-asp-phe-x3-xi8308, wherein X1 is the amino acid selected from ser, Cys, Lys and ASP； Glu and unnatural amino acids, whose transverse chain includes functional sulfuryl group, amino group or carbohydrate group； or the selected sequence between tetrapeptide group, pentapeptide group and hexapeptide group； X2 is Gly or D-Ala amino acid；X3 is an amino acid selected from Leu, Cys, Lys, ASP, Glu and an unnatural amino acid group. Its transverse chain includes functional sulfuryl group, amino group or carboxyl group. X-8308 is optional and an amino acid selected from the compound group, Cys, Lys, ASP, Glu and an unnatural amino acid, the transverse chain of which includes functional sulfuryl group, amino group or carboxyl group； (b) an optional N-terminal segment, before (a)；cuya secuencia aminoac dica es X -Asp-Thr-Val-X -X -X -X donde X es un amino cido seleccionado del grupo compuesto por Asn D-Asp D-Glu D-Gln y D-Ala y se encuentra enlazado por and said peptide bond comprises the carbonyl group of the main chain of the residue X⁻¹ and the amino group of the main chain of the residue X⁻¹ of the segment described in a)；X es un amino cido seleccionado del grupo compuesto por Phe Cys Lys Asp Glu y un amino cido no natural cuya cadena lateral comprende el grupo funcional sulfhidrilo el grupo amino o el grupo carboxilo X es un amino cido selecciona
