The present Invention relates to compounds of the f u00f3rmulaen: R1 is Hydrogen, Lower alkyl, cyano, halogen, alkoxy alkyl substituted by Halogen, Lower, Lower, Lower alkoxy substituted by Halogen or C (o) NH2, phenyl optionally substituted by Halogen or cyano, or Lac Oxy substituted by Halogen or lower, is 2.2 - difluorbenzo [d] [1,3] dioxol - 5 - iloOr is 6 - (trifluoromethyl) - pirazin thiocyanatoacetate or 5 - (trifluoromethyl) pirazin thiocyanatoacetate or is 6 - (trifluoromethyl) pyrimidine - ilo 4, or 6 - (trifluoromethyl) - pyridin - 3 - or 5 - ILO, ILO is cianopirazin - 2 or - 2 - (Tri fluormetil pyrimidin-2-yl) - 4 - ilo； n is the Number 1 or 2r2 is Halogen or lower alkyl, cyano and R3 is Hydrogen, OR2 And R3 is Hydrogen or Halogen, cyano Lower alkyl； X is a Link ID ',- ch2nh - or - CHR '-； R is Hydrogen or lower alkyl； Z is a Link, - CH2 - u OR - ar is phenyl or heteroaryl is chosen from the group formed by 1H - indazol pyridin - ILO - 3, - 2 - 3 - pyridin - ILO, ILO, pyridin - 4 - 5 - Ilo Ilo, pyrimidine, 1h pyrazole - 3 - ilo1h pyrazole - ILO - 4 and 5 - ILO - 1H pyrazole； or an Acid Addition Salt of a pharmaceutically suitable of the same； that can be used for the treatment of depression, Anxiety Disorders, bipolar disorder, Attention deficit hyperactivity disorder (ADHD), trastorn I stress related, psychotic disorders, Schizophrenia, neurological diseases,Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, Epilepsy, Migraine, hypertension, Substance Abuse disorders, Metabolic Disorders, food intake, diabetes, complications of diabetes, obesity, dislipide Mia, disorders of energy consumption and assimilation.The disruption and malfunction of the homeostasis of body temperature, sleep and Circadian Rhythm Disorders and cardiovascular disorders.Даний винахід стосується сполуки формули, (I)деRозначає водень, галоген, ціаногрупу, нижчий алкіл, нижчий алкіл, заміщений галогеном, нижчу алкоксигрупу, нижчу алкоксигрупу, заміщену галогеном,
