HAANING, JESPER MORTENSEN,ANDERSEN, KIM VILBOUR,BORNAES, CLAUS
申请号：
NZ58758004
公开号：
NZ587580A
申请日:
2004.06.18
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Provided is a conjugate comprising a Factor VII (FVIl) or Factor VIIa (FVlla) polypeptide variant having an amino acid sequence that differs in 1·15 amino acid residues relative to the amino acid sequence of human Factor VII (hFVII) or human Factor VIla (hFVIIa) shown in SEQ ID NO:I, wherein a negatively charged amino acid residue has been introduced by substitution in position 36 in the variant sequence, conjugated to a biocompatible polymer. The conjugates can be used to treat diseases in which inducing blood clot formation is beneficial, e.g. hemorrhage, variceal bleeding and hemophilia.
