Methods for rapidly preventing, controlling, or stopping the spread of Avian Influenza Virus (AIV) in the housing of a poultry flock in need thereof are provided, comprising, applying a composition to the floor of said housing in amounts effective to rapidly inactivate AIV, said composition comprising (i) salicylic acid; and (ii) one or more mineral salts, wherein said inactivation occurs within about ten to fifteen minutes after application of said composition, thereby preventing, controlling, or stopping the spread of AIV in said housing.