NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
发明人:
Ken-ichiro SEINO,Muhammad BAGHDADI
申请号：
US15736203
公开号：
US20180193453A1
申请日:
2016.06.16
申请国别(地区):
US
年份:
2018
代理人:
摘要：
[Problem] To provide a treatment-resistance reducing agent for treatment-resistant cancer, said treatment-resistance reducing agent being capable of eliminating or reducing treatment-resistance, in particular, drug-resistance of cancer and thus enhancing the efficacy of cancer treatment.[Solution] A treatment-resistance reducing agent for treatment-resistant cancer that contains, as active ingredient(s), a substance specifically inhibiting the binding of interleukin-34 to colony stimulating factor-1 receptor and/or a substance suppressing the expression of interleukin-34 in a cancer cell. According to the present invention, the treatment resistance of cancer, which is resistant to a treatment method such as the administration of an anticancer agent or radiation therapy, can be reduced and, therefore, the efficacy of cancer treatment can be enhanced and the occurrence risk of a side effect can be suppressed.
