TREATMENT OF INFLAMMATORY CONDITIONS AND IMPROVEMENT OF HYGIENIC CONDITION OF THE ORAL CAVITY BY USING AGENTS CONNECTING METALS AND METHYL SULPHONYLMETHANE AS AN AMPLIFIER OF THEIR VEHICLE
БХУШАН Раджив (US);ДЖИН Джерри Б. (US);ГОСВАМИ Амит (US)
发明人:
БХУШАН Раджив (US),ДЖИН Джерри Б. (US),ГОСВАМИ Амит (US)
申请号：
RU2014148805
公开号：
RU2014148805A
申请日:
2013.05.03
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. An oral composition comprising a biocompatible chelating agent at a concentration of at least 0.1% (w / w) and a permeation enhancer at an effective concentration. The composition of claim 1, wherein the carrier is at least partially aqueous. A composition according to claim 2, containing a solution. A composition according to claim 2, containing a suspension. 5. The composition of claim 2, wherein the carrier also includes a water-swellable polymer, and the composition is a hydrogel. A composition according to claim 2, in which the carrier also contains a polymer that forms a thermally dependent hydrogel, so that the composition after administration to the body forms an in situ hydrogel. The composition of claim 1, wherein the carrier is an ointment base, and the composition is an ointment. The composition of claim 1, wherein the carrier is a lotion base, and the composition is a lotion. The delivery system of a therapeutic agent for the oral cavity containing the liposome dispersion of the composition according to p. 1.10. The delivery system of a therapeutic agent according to claim 9, containing a colloidal suspension of microspheres, nanospheres, microparticles or nanoparticles containing the composition according to claim 1.11. The composition of claim 1, wherein the biocompatible chelating agent is selected from ethylenediaminetetraacetic acid (EDTA), cyclohexanediaminetetraacetic acid (CDTA), hydroxyethylethylene diamine triacetic acid (HEDTA), diethylene triamine pentaacetic acid (DPTA) dimethanopropane dimethanopropane dimethanopropane dimethanopropane dimethanopropane dimethanopropane dimethanopropane aminotrimethylene phosphonic acid (ATRA), citric acid, curcumin and their acceptable salts and combinations of these substances. 12. The composition of claim 11, wherein the biocompatible chelating agent is EDTA or its acceptable salts.1. Композиция для полости рта, содержащая биологически совместимый хелатирующий агент в концентрации по меньшей мере 0,1%
