An anchoring system includes a device which permits a portion of a catheter or similar medical article to be easily anchored to a patient, desirably without the use of tape or needles and suture. The anchoring system comprises an anchor pad and a retainer mounted upon the anchor pad. The retainer includes at least one clip forming at least a portion of a central channel and that moves generally in a lateral direction to capture the medical article to be retained. In certain embodiments, the clip moves in lateral and transverse directions between closed and open positions. The medical article is secured within the central channel. The channel may have a straight or tapering shape depending on the medical article to be retained.