A uniform cluster of nanocompositions suspended in a liquid media is provided. Methods of making such nanocompositions, and uses of such nanocompositions are also provided. The nanocompositions can be used for nucleic acid extraction and diagnostic assays, for immunoassays, for cell separation, identification and modulation, for controlled functional molecule protection and release, for assays used in the clinic (companion diagnostics) or in the therapeutic development process (drug target validation), and in a system for transcatheter arterial chemoembolization, and demonstrate superior performance due to the uniform property or monodispersity.