PROBLEM TO BE SOLVED: To provide compositions for preventing and/or treating diseases involving aberrant angiogenesis, which demonstrate anti-proliferative effects against human endothelial cells for the treatment of a variety of diseases, including, but not limited to, cancer, in addition to an inhibitory effect directly on cancer cells for the treatment of tumors, or on other cells that act as an initiator of angiogenesis in diseases other than cancer.SOLUTION: The composition comprises a compound represented by Formula (I) (X is O, N or S； R1-R5 and R7 are independently H, an alkyl or the like； H6 and R8 are H).【課題】腫瘍治療のため癌細胞に直接、又は癌以外の疾患の血管新生イニシエーターとして作用する他の細胞に阻害効果を示すことに加えて、癌に限定されないがこれをはじめとする様々な疾患の治療のため、ヒト内皮細胞に抗増殖性効果を示す、異常な血管新生が関与する疾患を予防及び／又は治療する組成物の提供。【解決手段】式（I)で表される化合物などを含む組成物。（ＸはＯ、Ｎ又はＳ；Ｒ１～Ｒ５及びＲ７は独立にＨ，アルキル等；Ｈ６及びＲ８はＨ）【選択図】なし
